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[Clinical studies in prostatic carcinoma]

Kh Kumanov, M Tsvetkov

    Khirurgiia
    |January 1, 1993
    PubMed
    Summary
    This summary is machine-generated.

    This study investigated a combined therapy for advanced prostate cancer (stage T3-T4). The treatment, including cyproterone acetate, achieved disease control in 72% of patients, with observed changes in microelement levels.

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    Area of Science:

    • Oncology
    • Urology
    • Endocrinology

    Background:

    • Prostate carcinoma, particularly at advanced stages (T3-T4), presents significant clinical challenges.
    • Effective therapeutic strategies for advanced prostate cancer are crucial for patient outcomes.

    Purpose of the Study:

    • To evaluate a combined therapeutic approach for stage T3-T4 prostate carcinoma.
    • To assess the impact of this combined therapy on microelement levels and prostate-specific antigen (PSA).

    Main Methods:

    • Clinical observation of 269 patients with stage T3-T4 prostate carcinoma.
    • Combined therapy involving cyproterone acetate, with supplementary orchiectomy or transurethral resection in select cases.
    • Monitoring of microelement levels (copper, zinc, iron) and prostate-specific antigen post-treatment.

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    Main Results:

    • Successful disease control was achieved in 72% of patients after a 3-month treatment course.
    • Changes in copper, zinc, and iron levels were recorded.
    • A decrease in prostate-specific antigen levels was observed in some patients.

    Conclusions:

    • The combined therapeutic approach shows promise for managing advanced prostate carcinoma.
    • Further research into the role of microelements in prostate cancer treatment is warranted.