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The abundance of mRNA for dopamine D2 receptor isoforms in brain tissue from controls and schizophrenics
D A Roberts1, D Balderson, S M Pickering-Brown
1Division of Neuroscience, University of Manchester, UK.
Brain Research. Molecular Brain Research
|August 1, 1994
Abstract:
The possibility that schizophrenia is associated with a differential expression, in the brain, of the short and long isoforms of the dopamine D2 receptor has been investigated by assessing the abundance of mRNA for each of the isoforms. Using a quantitative RNA-PCR technique, increased mRNA for both isoforms of the D2 receptor were observed in some brain regions, with no differential distribution between the isoforms in the schizophrenics compared to controls.