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Identification of the triggers of celiac sprue
1Division of Digestive Diseases and Nutrition, University of Massachusetts Medical Center, Worcester 01655.
Nutrition Reviews
|September 1, 1994
Abstract:
Three theoretically antigenic synthetic peptide subunits of alpha-gliadin were evaluated in vivo in four patients with celiac disease. A sequence of alpha-gliadin (amino acids 31-49) was toxic in all patients, suggesting that this sequence is one of the triggers of the immune system in celiac sprue.