Study on the insulin-binding capacity of blood serum by a cellulose adsorption method

The cellulose adsorption method was used for the quantitative study of the insulin-binding capacity of blood serum. The results support the view that anti-bodies to insulin are of exogenous origin and that may be responsible for insulin resistance in individual cases. While the insulin requirement of patients was found to be related to the serum antibody level, the latter was unaffected by the duration of insulin treatment even though the number of cases exhibiting normal values decreased with the length of treatment.