Related Experiment Video
Updated: Aug 9, 2026

Protocol for Culturing Sympathetic Neurons from Rat Superior Cervical Ganglia (SCG)
Published on: January 30, 2009
Nerve growth factor: pathophysiological and therapeutic implications
Abstract:
Neurotrophic factors are target-derived proteins capable of affecting survival, target innervation, and/or function of neuronal cell populations. Nerve growth factor (NGF) is the best-studied member of the genetic family called neurotrophins. There is however little knowledge whether other neurotrophins play a pathophysiological role in diseases of the peripheral and central nervous system. An increasing number of animal studies suggest that NGF plays a role in (a) peripheral nerve regeneration, (b) diabetic neuropathy, and (c) age-related neurodegenerative processes within the brain.
Related Concept Videos
Enzyme-linked Receptors
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Mitogens and the Cell Cycle
Regulation of Angiogenesis and Blood Supply
Neurogenesis and Regeneration of Nervous Tissue

