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Related Experiment Videos

[Sjögren's syndrome and virus]

X Mariette1

  • 1Service d'immunopathologie et d'hématologie, laboratoire d'immunopathologie, hôpital Saint-Louis, Paris, France.

La Revue De Medecine Interne
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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Viruses like Epstein-Barr virus (EBV) and human T-lymphotropic virus type 1 (HTLV-I) may trigger Sjögren

Area of Science:

  • Virology
  • Immunology
  • Pathogenesis

Context:

  • Sjögren's syndrome (SS) is an autoimmune disorder characterized by lymphoid proliferation.
  • The role of viral infections in SS pathogenesis is under investigation.

Purpose:

  • To explore the potential involvement of herpesvirus, retrovirus, and hepatitis C virus (HCV) in Sjögren's syndrome.

Summary:

  • Epstein-Barr virus (EBV) genes/proteins found in salivary/lacrimal glands of SS patients.
  • Endogenous retroviral sequences detected more frequently in SS salivary glands.
  • HTLV-I tax gene expression observed in SS patients without HTLV-I infection markers.
  • Sicca syndrome in viral infections may differ from classical autoimmune SS.

Impact:

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  • Suggests viruses may initiate lymphoid proliferation and gland destruction in genetically susceptible individuals.
  • Highlights the oropharynx as a potential viral latency site.
  • Implicates specific viruses in the pathogenesis of Sjögren's syndrome.