Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apparent lymph node primary gastrinoma

W S Arnold1, D L Fraker, H R Alexander

  • 1Surgical Metabolism Section, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892.

Surgery
|December 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the immediate impact of COVID-19 on surgical oncology practice: Experience from an NCI-designated Comprehensive Cancer Center in the Northeastern United States.

Journal of surgical oncology·2021
Same author

Sentinel lymph node positivity and overall survival in immunosuppressed patients with Merkel cell carcinoma: a national cohort study.

The British journal of dermatology·2020
Same author

<i>SDHB</i> mutation carriers with malignant pheochromocytoma respond better to CVD.

Endocrine-related cancer·2017
Same author

Lymph node evaluation and survival after curative-intent resection of duodenal adenocarcinoma: A matched cohort study.

European journal of cancer (Oxford, England : 1990)·2016
Same author

Preoperative radiotherapy in the management of retroperitoneal liposarcoma.

The British journal of surgery·2016
Same author

Treasure of the Past: II: The Atomic Weight of Bromine.

Journal of research of the National Institute of Standards and Technology·2016
Same journal

Imaging-guided classification and diagnostic pathways for appendiceal abscesses: Results from the 2025 Italian Society of Research in Surgery/Italian Society of Emergency and Trauma Surgery consensus conference.

Surgery·2026
Same journal

Reappraising the role of angiography in managing intraluminal postpancreatoduodenectomy hemorrhage: Analysis of 115 cases from 3,011 consecutive pancreatoduodenectomies.

Surgery·2026
Same journal

Combining indocyanine green fluorescence imaging and ultrasound intraoperatively to visualize primary and secondary cancerous lesions in the liver: Systematic review and meta-analysis.

Surgery·2026
Same journal

The negative impact of prolonged staging-to-resection interval on upstaging status in patients with lung adenocarcinoma.

Surgery·2026
Same journal

Observational methods in surgical settings.

Surgery·2026
Same journal

Safe local management of mild traumatic brain injury: Reducing unnecessary transfers to higher-level trauma centers.

Surgery·2026
See all related articles

Resection of lymph node (LN) primary gastrinoma is effective for Zollinger-Ellison syndrome (ZES). A significant percentage of patients remain disease-free after surgery, indicating LN gastrinomas warrant surgical consideration.

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Gastroenterology

Background:

  • The origin of gastrinoma, a neuroendocrine tumor, in lymph nodes (LNs) causing Zollinger-Ellison syndrome (ZES) remains debated.
  • This study investigates the outcomes of patients with ZES where gastrinomas were exclusively found and removed from LNs.

Purpose of the Study:

  • To evaluate the efficacy and long-term outcomes of surgical resection for primary lymph node gastrinomas in patients with Zollinger-Ellison syndrome.
  • To determine if lymph node gastrinomas are a distinct entity and amenable to curative treatment.

Main Methods:

  • A retrospective review of 110 patients with ZES who underwent surgical exploration between 1982 and 1992.
  • Twenty-one patients (19%) had disease confined to LNs. Surgical exploration involved intraoperative ultrasonography, endoscopy, and duodenotomy.

Related Experiment Videos

  • Patients were followed annually with biochemical and radiological assessments.

    • Main Results:

    • Of 21 patients with LN-only gastrinomas, 13 (62%) achieved initial biochemical cure.
    • Four of these 13 patients experienced biochemical recurrence after a median of 4.2 years.
    • Nine patients (43%) remained biochemically cured with no evidence of disease at a median follow-up of 5.3 years.

    Conclusions:

    • Surgical resection of apparent primary lymph node gastrinomas is a justifiable treatment for Zollinger-Ellison syndrome.
    • A substantial proportion of patients (43%) achieved long-term biochemical cure, supporting the concept of LN primary gastrinomas as treatable lesions.