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In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
Published on: May 4, 2017
[Therapeutic plasmapheresis in immune complex diseases]
Terapevticheskii Arkhiv
|January 1, 1994
Summary
Plasmapheresis procedures effectively manage plasma protein and volume changes in patients. Safe protocols exist for salt, dextran, or albumin solutions, with regression modeling aiding proteinemia prediction.
Area of Science:
- Nephrology
- Hematology
- Biochemistry
Background:
- Immune thrombocytopenic purpura and bronchial asthma patients undergo plasmapheresis.
- Understanding plasma protein and volume dynamics is crucial for patient management.
- Exfusion volume, substitution solution type, and composition influence outcomes.
Purpose of the Study:
- To investigate the impact of plasmapheresis parameters on plasma protein and volume.
- To establish safe procedural limits for different substitution solutions.
- To evaluate mathematical models for predicting post-plasmapheresis proteinemia.
Main Methods:
- Analysis of 140 plasmapheresis procedures in patients with immune thrombocytopenic purpura and bronchial asthma.
- Monitoring of plasma protein and volume changes.
- Testing three mathematical models for post-plasmapheresis proteinemia prediction.
Main Results:
- Plasma protein system changes correlated with the plasmapheresis procedure regimen.
- Safe procedures were identified: up to 30% plasma volume removal with salt solution, 50% with dextran, and 95% with albumin.
- The regression equation Ct = a0 + a1.Co was identified as the most adequate model for predicting proteinemia.
Conclusions:
- Plasmapheresis can be performed safely with specific volume and substitution guidelines.
- The chosen mathematical model accurately predicts post-plasmapheresis proteinemia.
- This research provides valuable insights for optimizing plasmapheresis protocols.
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