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[Measles vaccination and age]

P Aaby1, M Andersen, M Sodemann

  • 1Statens Seruminstitut, København.

Ugeskrift for Laeger
|October 3, 1994
PubMed
Summary

Early measles vaccination (4-8 months) in Guinea-Bissau was linked to lower childhood mortality, contrary to previous findings. This suggests early immunization may be safe and beneficial for child survival.

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Area of Science:

  • Pediatrics
  • Immunology
  • Global Health

Background:

  • Recent studies suggested high-titre measles vaccine before 9 months may reduce survival.
  • This raised concerns about the safety of early infant immunization.

Purpose of the Study:

  • To examine the safety and impact of early measles vaccination (Schwarz vaccine) on child mortality in Guinea-Bissau.
  • To compare mortality rates between children vaccinated before and after 9 months of age.

Main Methods:

  • Retrospective analysis of immunization campaigns in Guinea-Bissau (1980-1983).
  • Follow-up of children until age five, death, or migration.
  • Comparison of mortality rates based on vaccination age (4-8 months vs. 9-11 months).

Main Results:

  • Children vaccinated at 4-8 months showed lower mortality between 9 months and 5 years compared to those vaccinated at 9-11 months.
  • Improved survival was independent of better measles protection.
  • No socio-cultural differences were found between vaccination groups.

Conclusions:

  • Vaccination before 9 months of age appears safe and may reduce overall childhood mortality.
  • Findings challenge the current recommended measles immunization strategy in developing countries.
  • Randomized trials are recommended to confirm these observations and inform policy.

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