Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dystrophy-like myopathy in a foal

G Sarli1, L Della Salda, P S Marcato

  • 1Istituto di Patologia Generale e Anatomia Patologica Veterinaria, Bologna, Italy.

The Veterinary Record
|August 13, 1994
PubMed
Summary

This study examined muscle biopsies from a young Standardbred trotter exhibiting hypertrophy and hypertonicity. Histological findings revealed significant abnormalities, suggesting a condition similar to human muscular dystrophy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computer-aided image analysis for PD-L1 assessment in canine urothelial carcinoma.

Veterinary journal (London, England : 1997)·2026
Same author

Tumor immune microenvironment and immune phenotypes in PD-L1-tested canine urothelial carcinoma.

BMC veterinary research·2025
Same author

It is not always what it seems: allantochorion cervical pole necrosis.

Journal of equine veterinary science·2025
Same author

HER2 Overexpression and Cytogenetical Patterns in Canine Mammary Carcinomas.

Veterinary sciences·2022
Same author

Standardized approach for evaluating tumor infiltrating lymphocytes in canine mammary carcinoma: Spatial distribution and score as relevant features of tumor malignancy.

Veterinary journal (London, England : 1997)·2022
Same author

Red mark syndrome of trout (Oncorhynchus mykiss; Walbaum, 1792): Histopathological scoring and correlation with gross lesions.

Journal of fish diseases·2021

Area of Science:

  • Equine myology
  • Veterinary pathology
  • Comparative neuromuscular disease

Background:

  • A six-month-old Standardbred trotter presented with clinical signs of muscle hypertrophy and hypertonicity.
  • Electromyography confirmed myotonic discharges in multiple hindlimb muscles, indicating neuromuscular dysfunction.

Purpose of the Study:

  • To histologically, histochemically, and ultrastructurally examine muscle biopsies from an affected equine patient.
  • To characterize the pathological changes in equine muscle tissue.
  • To compare findings with human muscular dystrophy.

Main Methods:

  • Histological examination of gluteus medius and semitendinosus muscle biopsies.
  • Histochemical staining to analyze muscle fiber types and characteristics.
  • Ultrastructural analysis using electron microscopy.

Main Results:

  • Observed variations in muscle fiber size and shape, including vacuolization, hyalinization, and fiber splitting.
  • Increased internal nuclei, connective tissue, and fat infiltration were noted.
  • Muscle hypertrophy and a predominance of type I fibers were evident, along with fiber type grouping.

Conclusions:

  • The observed histological features in the equine muscle biopsies closely resemble those seen in human muscular dystrophy.
  • These findings suggest a potential shared pathological pathway or a similar disease entity in equine and human muscular disorders.

Related Experiment Videos