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[Role of the individual sensitivity to various cytostatic agents in children with neuroblastomas]
Abstract:
Primary plasmic cultures of 33 tumors of the sympathic nervous system of children (27 neuroblastomas and 6 ganglioneuromas) were used for determination of their individual sensitivity to vincristin, vinblastin, dactinomycin, mithramycin, olivomycin, cyclophosphant bruneomycin and adriamycin. Most of the tumors were sensitive to vincristin, rubomycin an adriamycin. The data obtained in vitro and in the clinic were compared with respect to 12 cases (treatment with vincristin, combination of olivomycin with cyclophosphan, vincristin with rubomycin or cyclophosphan). Coinsidence of the results was observed in 8 cases. The method of primary plasmic cultures may be successfully used for determination of individual sensitivity of children with neuroblastomas to various cytostatics.
Insights
Primary tumor cultures accurately predict patient response to chemotherapy. This method helps tailor neuroblastoma treatments, improving outcomes for children with these nervous system tumors.
Area of Science:
- Pediatric Oncology
- Pharmacology
- Cancer Biology
Background:
- Neuroblastomas and ganglioneuromas are common pediatric nervous system tumors.
- Determining individual tumor sensitivity to chemotherapy is crucial for effective treatment.
Purpose of the Study:
- To evaluate the efficacy of primary tumor cultures in predicting children's individual sensitivity to various chemotherapeutic agents.
- To compare in vitro drug sensitivity data with clinical outcomes.
Main Methods:
- Primary tumor cultures were established from 33 pediatric tumors (27 neuroblastomas, 6 ganglioneuromas).
- Tumor sensitivity was tested against vincristine, vinblastine, dactinomycin, mithramycin, olivomycin, cyclophosphamide, bruneomycin, and adriamycin.
- In vitro results were compared to clinical data from 12 patients.
Main Results:
- Most tumors exhibited sensitivity to vincristine, rubomycin, and adriamycin.
- A significant coincidence (8 out of 12 cases) was observed between in vitro sensitivity predictions and clinical treatment responses.
- Primary tumor cultures demonstrated successful prediction of patient response.
Conclusions:
- Primary tumor cultures are a viable method for determining individual cytostatic sensitivity in pediatric neuroblastomas.
- This approach can guide personalized chemotherapy selection for improved treatment efficacy.
- The findings support the use of in vitro drug sensitivity testing in pediatric oncology.