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Monosomy 7 myelodysplasia in childhood. Two case reports
M A Yeşilipek1, G Lüleci, S Velipaşaoğlu
1Akdeniz University Medical School, Department of Pediatric Hematology and Medical Biology, Antalya, Turkey.
Insights
Infantile monosomy 7 myelodysplasia is a rare condition in children that can progress to leukemia. Routine chromosomal analysis is crucial for diagnosing myelodysplasia and related leukemias.
Area of Science:
- Hematology
- Pediatric Oncology
- Cytogenetics
Background:
- Monosomy 7 myelodysplasia is a rare hematological disorder.
- It is characterized by bone marrow and peripheral smear abnormalities.
- This condition has a poor prognosis in children.
Abstract:
Monosomy 7 myelodysplasia is a rare hematological entity and is associated with morphological abnormalities in bone marrow and peripheral smear, and poor prognosis in children. We describe 2 children with infantile monosomy 7 myelodysplasia which evolved to leukemia. One of them died after 1 month, and the other is still on therapy for acute myelocytic leukemia (M4) which has evolved from chronic myelomonocytic leukemia. We concluded that chromosomal analysis must be done routinely in patients with myelodysplasia, in acute myeloid leukemia and chronic myelomonocytic leukemia.