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[Effect of gonadotropin-releasing peptide (GRP) on LH secretion of mouse pituitary in vitro]
1Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical University, Beijing.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1994
Abstract:
Synthetic GRP and its analogues, GRP-NH2, [Glu7.9.14 Lys6.10] GRP (6-14), [Phe14] GRP (5-14) and [Phe14] GRP, at the concentration of 0.05 mmol.L-1 were shown to have stimulatory effect on LH secretion in cultured mouse pituitary in vitro. The luteotropin releasing activity of GRP and its analogues was estimated to be 115.4, 114.2, 140.0, 162.0 and 179.0% of the control group, respectively. Subcutaneous administration of [Phe14] GRP on days 7-9 and 1-5 of pregnancy and [Phe14] GRP (5-14) on days 2-4 of gestation at dosage of 1 mg.d-1 (each mouse) caused fetal death in 40-60% of mice.