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Related Experiment Videos

Hemimegalencephaly: a longitudinal MR study

S M Wolpert1, A Cohen, M H Libenson

  • 1Section of Neuroradiology, New England Medical Center Hospitals, Boston, MA.

AJNR. American Journal of Neuroradiology
|September 1, 1994
PubMed
Summary

Hemimegalencephaly can present as an enlarged hemisphere in infants, but later scans may show apparent micrencephaly due to differential growth. Early imaging is crucial for accurate diagnosis of this brain malformation.

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Area of Science:

  • Neurology
  • Pediatric Radiology
  • Developmental Neuroscience

Background:

  • Hemimegalencephaly is a rare congenital brain malformation characterized by unilateral enlargement of one cerebral hemisphere.
  • Accurate diagnosis is essential for appropriate management and understanding of neurodevelopmental outcomes.

Observation:

  • A case study involving an infant diagnosed with hemimegalencephaly.
  • Serial Magnetic Resonance (MR) imaging was performed at 5 days and 10 months of age.

Findings:

  • Initial MR scan at 5 days revealed an enlarged left cerebral hemisphere.
  • Follow-up MR scan at 10 months showed a smaller left cerebral hemisphere compared to the right.
  • This apparent left-sided micrencephaly resulted from normal growth of the right hemisphere and arrested development of the left.

Implications:

  • The timing of neuroimaging is critical for the correct diagnosis of hemimegalencephaly.
  • Understanding the dynamic changes in brain volume over time is important in diagnosing and managing pediatric brain malformations.
  • This case highlights the potential for misdiagnosis if serial imaging is not considered in hemimegalencephaly.

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