Related Experiment Videos
Combined treatment with terbutaline and aminophylline inhibits experimental amyloidosis in mice
S R Brandwein1, J D Sipe, A S Cohen
1Rush Medical College, Chicago, Illinois.
Arthritis and Rheumatism
|December 1, 1994
Abstract
Objective:
To investigate the effects of drugs known to elevate adenosine 3':5'-cyclic monophosphate (cAMP) on experimental amyloidosis.
Methods:
A beta 2-agonist, terbutaline, and a phosphodiesterase inhibitor, aminophylline, were administered in combination in a mouse model of amyloidosis induced by inflammatory stimulation with silver nitrate. Amyloidosis was quantitated by radioimmunoassay for splenic amyloid A (AA) protein.
Results:
At the doses selected, aminophylline/terbutaline inhibited splenic amyloid deposition more potently than did colchicine, a known inhibitor of amyloidosis.
Conclusion:
Drugs known to elevate cAMP inhibit experimental mouse AA amyloidosis.