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New 4-arylaminopiperidines with antihypoxic and anticonvulsive activity
G Domány1, G Barta-Szalai, E Pálosi
1Chemical Works of Gedeon Richter Ltd., Budapest, Hungary.
Arzneimittel-Forschung
|September 1, 1994
Abstract:
Several new bioanalogues of (+/-)-N-methyl-N-(1-[3-(4-fluorophenoxy)-2-hydroxy-propyl]piperidin++ +-4-yl) benzothiazol-2-amine (1, sabeluzole, CAS 104383-17-7) were prepared by reacting 1,2-epoxy-3-aryloxypropanes with 4-arylaminopiperidines. Some of these derivatives showed enhanced activity in the potassium cyanide hypoxia test and in the pentetrazol convulsion test in mice compared to 1.