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Monozygous twin with polymicrogyria and normal co-twin
1Department of Pediatrics; Tokyo Metropolitan Kita Medical and Rehabilitation Center Hospital for Handicapped, Japan.
Abstract:
Monozygous twinning has been associated with brain lesions such as holoprosencephaly, hydranencephaly, multicystic encephalomalacia, and porencephaly. Polymicrogyria is rare but has been reported in autopsied cases. We present a monozygotic twin with complicating twin-twin transfusion syndrome, the donor exhibiting normal psychomotor development and the recipient psychomotor delay associated with the brain anomaly, polymicrogyria. The brain anomaly might be due to blood pressure instability or a circulatory disturbance resulting from increased coagulability due to polycythemia.
Insights
This study details a rare case of polymicrogyria in a twin experiencing twin-twin transfusion syndrome. The affected twin showed developmental delays, potentially linked to circulatory issues.
Area of Science:
- Neurology
- Developmental Biology
- Genetics
Background:
- Monozygous (identical) twins share genetic material.
- Brain lesions like holoprosencephaly and porencephaly are known complications in monozygous twins.
- Polymicrogyria, a cortical malformation, is a rare but documented finding in autopsied twin cases.