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Local interferon therapy for lip carcinoma

D Ikić1, I Padovan, N Pipić

  • 1Department of Medicine, Croatian Academy of Sciences and Arts, Zagreb.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|January 1, 1994
PubMed
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Human natural leukocyte interferon (HNLI) showed an 81% response rate in lower lip cancer patients. This interferon therapy offers a promising alternative for lip carcinoma treatment, potentially reducing the need for surgery.

Area of Science:

  • Oncology
  • Immunotherapy

Background:

  • Squamous cell carcinoma and basal cell carcinoma are common lip malignancies.
  • Surgical intervention is the primary treatment, but alternative therapies are being explored.

Purpose of the Study:

  • To evaluate the efficacy of human natural leukocyte interferon (HNLI) and recombinant interferon alpha 2c in treating lip carcinomas.
  • To assess response rates and complete cure rates for these cancers.

Main Methods:

  • A prospective non-randomized study involving 21 patients with lower lip squamous cell carcinoma treated with HNLI.
  • Comparison with six lower lip squamous cell carcinoma cases treated with recombinant interferon alpha 2c.
  • Treatment of three basal cell carcinoma patients with HNLI.

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Main Results:

  • HNLI achieved an 81% response rate (size reduction >25%) and a 48% complete response rate in lower lip squamous cell carcinoma.
  • Recombinant interferon alpha 2c showed a 67% response rate and 17% complete response rate for the same condition.
  • All three basal cell carcinoma patients treated with HNLI achieved a complete cure.

Conclusions:

  • Interferon therapy, including HNLI, demonstrates significant efficacy in treating lip carcinomas.
  • Interferon presents a viable alternative or adjunct to surgical treatment for lip cancers.