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Lymphomatoid papulosis: a follow-up study of 41 patients
H K Christensen1, K Thomsen, G L Vejlsgaard
1Dermatological Department, Rigshospitalet, Copenhagen, Denmark.
Seminars in Dermatology
|September 1, 1994
Abstract:
Forty-one patients with lymphomatoid papulosis have been followed from 1 to 22 years (mean 11.4 years, median 10 years). Six patients developed malignant lymphoma, 3 cutaneous T-cell lymphoma, 2 Ki-1 large cell lymphoma, and 1 Hodgkin's disease. A clinical malignant presentation combined with the finding of aneuploidy in skin lesions seem to be indications of a malignant potential. Treatment with methotrexate in low dosage is an efficient treatment of lymphomatoid papulosis and probably diminishes the risk of malignancy.