[Early changes in transplants of lung organ cultures treated with several polycyclic hydrocarbons]

The authors examined the early changes in transplants from lung organ cultures treated with 64/ml of 3,4-benzpirene and 4 mg/ml of 20-methylholantrene. The bronchial cycst represented the most significant changes on the control transplants. In the transplants treated with two cancerogens there were several kinds of changes increasing with the advancement of the course of the transplantation-hyperplasia of lymphocytes, hyperplasia of the bronchial epithelium, gland-like structures and bronchial cysts. Besides this there were also tumours at the end of the third month in the transplants, treated with 20-methylcholantrene--in one of the transplants there was adenom and in another-carcinoma.