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Molecular cloning and functional expression of the guinea pig cardiac Na(+)-Ca2+ exchanger
1Department of Physiology, UCLA School of Medicine 90024-1760.
Abstract:
The cDNA of the guinea pig cardiac Na(+)-Ca2+ exchanger was cloned from a lambda ZAP cDNA library. The deduced sequence of the protein corresponds to 970 amino acids and is 98% identical to the canine cardiac exchanger. The leader peptide region shows substantial variation among species. The cloned cDNA can induce Na(+)-Ca2+ exchange activity when in vitro transcribed cRNA is injected into Xenopus laevis oocytes.
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