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Related Experiment Videos

Androgen receptor function during undernutrition

Q Dong1, H Rintala, D J Handelsman

  • 1Department of Obstetrics & Gynaecology, University of Sydney, Australia.

Journal of Neuroendocrinology
|August 1, 1994
PubMed
Summary
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Undernutrition enhances the negative feedback of androgens on reproductive hormones by increasing pituitary androgen receptor numbers, leading to suppressed gonadotropin secretion. This explains how food restriction impacts reproductive function.

Area of Science:

  • Reproductive Endocrinology
  • Neuroendocrinology
  • Nutritional Physiology

Background:

  • Undernutrition is known to inhibit reproductive function via the hypothalamo-pituitary axis.
  • The precise mechanisms suppressing gonadotropin secretion during food restriction remain unclear.
  • Enhanced testicular negative feedback on luteinizing hormone (LH) secretion is suggested during undernutrition.

Purpose of the Study:

  • To directly assess the suppression of hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator activity by endogenous androgens during food restriction.
  • To investigate the mechanisms behind enhanced testicular steroidal feedback during undernutrition.
  • To evaluate changes in androgen receptor binding in key brain and peripheral tissues.

Main Methods:

Related Experiment Videos

  • Intraventricular administration of an androgen receptor antagonist (hydroxyflutamide) to block cerebral androgens.
  • Measurement of circulating bioactive LH (bLH) levels in response to androgen blockade.
  • Assessment of androgen receptor binding capacity and affinity in the medio-basal hypothalamus, pituitary, and prostate of undernourished rats.

    • Main Results:

    • Hydroxyflutamide administration significantly increased bLH levels in both food-restricted and ad-lib fed rats.
    • Food-restricted rats exhibited a faster and greater increase in bLH levels post-hydroxyflutamide, indicating enhanced sensitivity to androgen feedback blockade.
    • Undernutrition increased androgen receptor binding capacity in the pituitary but not the hypothalamus or prostate, with no change in binding affinity.

    Conclusions:

    • Undernutrition enhances tonic, androgen receptor-mediated feedback suppression of GnRH secretion.
    • Increased pituitary androgen receptor numbers contribute to the inhibition of LH secretion during undernutrition.
    • These findings elucidate key neuroendocrine mechanisms linking nutritional status to reproductive suppression.