Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

p53 and human cancers

D P Lane1

  • 1Department of Biochemistry, University of Dundee, UK.

British Medical Bulletin
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Mutations in the tumor suppressor gene p53 are common in human cancers. Loss of p53 function elevates cancer risk, making it a key target for cancer therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simultaneous measurement of p53:Mdm2 and p53:Mdm4 protein-protein interactions in whole cells using fluorescence labelled foci.

Scientific reports·2019
Same author

Synthetic 10FN3-based mono- and bivalent inhibitors of MDM2/X function.

Protein engineering, design & selection : PEDS·2018
Same author

Enhancing Specific Disruption of Intracellular Protein Complexes by Hydrocarbon Stapled Peptides Using Lipid Based Delivery.

Scientific reports·2017
Same author

The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage.

Oncogene·2016
Same author

p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration.

Cell death and differentiation·2016
Same author

Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish.

Oncogene·2015
Same journal

Human health in relation to visible, functional, and accessible green space: a systematic review and narrative synthesis of the 3 + 30 + 300 guideline.

British medical bulletin·2026
Same journal

Muscle herniae in exercise-induced leg pain: diagnostic pitfalls and the 'repair paradox'.

British medical bulletin·2026
Same journal

Scaffolds and platelet concentrates in bone regenerative medicine: applications, mechanisms, and future approaches.

British medical bulletin·2026
Same journal

Back squat and deadlift fatiguing protocols elicit distinct countermovement jump profiles: phase-specific predictors and soreness responses.

British medical bulletin·2026
Same journal

Enhancing bone healing through osteogenic medium components: biological roles, mechanisms, and clinical applications.

British medical bulletin·2026
Same journal

Moral injury in healthcare workers: causes & interventions.

British medical bulletin·2026
See all related articles

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The p53 gene is a crucial tumor suppressor.
  • Mutations in the p53 gene are frequently observed in human cancers.
  • Normal p53 function is essential for preventing cancer development.

Purpose of the Study:

  • To investigate the role of the p53 gene in cancer.
  • To understand the mechanisms by which p53 loss contributes to tumorigenesis.
  • To identify p53 as a potential therapeutic target in cancer treatment.

Main Methods:

  • Analysis of p53 gene mutations in human cancer samples.
  • Studying the function of p53 protein in response to genotoxic stress.
  • Investigating mechanisms of p53 inactivation in tumor cells.

Related Experiment Videos

Main Results:

  • p53 gene mutations are among the most common genetic alterations in human cancer.
  • Loss of p53 function significantly increases cancer susceptibility.
  • p53 protein levels rise upon genotoxic stimuli, initiating cell death pathways.
  • Many tumor cells inactivate p53 through mutation or protein binding, losing this protective response.

Conclusions:

  • The p53 gene acts as a critical tumor suppressor.
  • Inactivation of p53 is a key event in the development of many cancers.
  • Restoring p53 function or its response to DNA damage presents a promising therapeutic strategy for cancer intervention.