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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Relation between changes in severity of coronary artery stenosis and anginal patterns

J N Karnegis1, J P Matts, N Tuna

  • 1University of Nebraska, Omaha.

Catheterization and Cardiovascular Diagnosis
|August 1, 1994
PubMed

Insights

Angina pectoris symptoms did not correlate with coronary artery stenosis severity changes over three years in a study of 376 individuals. This research explored the relationship between angina status and coronary artery disease progression.

Area of Science:

  • Cardiology
  • Medical Research

Background:

  • Myocardial ischemia is a known cause of angina pectoris.
  • A direct correlation between angina severity and coronary artery stenosis severity is not consistently observed in individuals.
  • Longitudinal changes in anginal status relative to coronary artery stenosis severity have not been previously investigated.

Purpose of the Study:

  • To investigate the relationship between changes in anginal status and changes in coronary artery stenosis severity over a three-year period.
  • To determine if longitudinal changes in angina correlate with progression or regression of coronary artery disease.

Main Methods:

  • Utilized coronary arteriogram data from 376 control subjects in the Program on the Surgical Control of the Hyperlipidemias (POSCH).
  • Coronary arteriograms were performed at study entry and at a 3-year follow-up.
  • Arteriograms were blindly graded for changes in coronary artery stenosis severity by the POSCH Arteriography Review Committee.

Main Results:

  • No statistically significant relationship was found between the presence, absence, development, or disappearance of angina pectoris.
  • Changes in coronary artery stenosis severity over three years did not correlate with changes in anginal status.
  • Analysis included 376 control subjects (347 men, 29 women).

Conclusions:

  • Long-term changes in angina pectoris do not appear to correlate with changes in coronary artery stenosis severity.
  • The study suggests that anginal status may not be a reliable indicator of coronary artery disease progression or regression over a three-year period.

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