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Infertility, obstetric and gynaecological problems in coeliac sprue
K S Sher1, V Jayanthi, C S Probert
1Leicester General Hospital, UK.
Digestive Diseases (Basel, Switzerland)
|May 1, 1994
Summary
Coeliac sprue significantly impacts fertility in both men and women, causing various reproductive issues. Dietary changes, including gluten withdrawal and nutrient correction, can restore fertility.
Area of Science:
- Reproductive Endocrinology
- Gastroenterology
- Human Nutrition
Background:
- Coeliac sprue is linked to infertility in both sexes.
- Reproductive disturbances in women include delayed menarche, amenorrhea, early menopause, and reduced pregnancy rates.
- Men may experience hypogonadism, immature secondary sex characteristics, and reduced semen quality.
Purpose of the Study:
- To explore the association between coeliac sprue and infertility.
- To elucidate the mechanisms underlying coeliac sprue-induced reproductive dysfunction.
- To assess the impact of treatment on fertility in coeliac patients.
Main Methods:
- Review of existing evidence on coeliac sprue and reproductive health.
- Analysis of potential contributing factors like malnutrition and specific nutrient deficiencies.
- Investigation into hormonal pathways, including testosterone conversion and hyperprolactinemia.
Main Results:
- Coeliac sprue is associated with a range of fertility issues in men and women.
- Mechanisms may involve malnutrition, deficiencies in iron, folate, and zinc.
- Reduced testosterone to dihydrotestosterone conversion and hyperprolactinemia are implicated in male reproductive dysfunction.
Conclusions:
- Coeliac sprue significantly affects male and female fertility through various mechanisms.
- Nutritional deficiencies and hormonal imbalances play crucial roles.
- Gluten withdrawal and nutritional correction can reverse fertility impairments.