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Related Experiment Videos

Heart rate variability during sleep in infants with bronchopulmonary dysplasia. Effects of mild decrease in oxygen

S I Filtchev1, L Curzi-Dascalova, L Spassov

  • 1INSERM CJF 89-09, Laboratoire de Physiologie, Hôpital Antoine Béclère, Clamart, France.

Chest
|December 1, 1994
PubMed
Summary

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Infants with severe bronchopulmonary dysplasia (BPD) show altered autonomic nervous system control of heart rate during sleep. Mild decreases in arterial oxygen saturation (SaO2) exacerbate these autonomic dysfunctions.

Area of Science:

  • Pediatric Pulmonology
  • Autonomic Nervous System Physiology
  • Neonatal Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants.
  • Autonomic nervous system (ANS) dysfunction is common in infants with severe BPD.
  • Sleep stages and arterial oxygen saturation (SaO2) can influence ANS activity.

Purpose of the Study:

  • To investigate heart rate modulation by the ANS in infants with severe BPD.
  • To examine the relationship between sleep stages, SaO2 levels, and ANS activity.
  • To determine if mild hypoxemia exacerbates ANS abnormalities in BPD.

Main Methods:

  • Polygraphic recordings in 10 oxygen-dependent infants (7-29 months) with severe BPD.
  • Analysis of heart rate variability (HRV) in low (LF) and high (HF) frequency bands.

Related Experiment Videos

  • Comparison of HRV during normal SaO2 (>95%) and mild decrease (90-94%) across sleep stages (REM, NREM stage 2).

    • Main Results:

    • In normal SaO2, LF was lower in REM sleep than NREM stage 2, contrary to typical findings.
    • Mild SaO2 decrease (<95%) led to increased heart and respiratory rates.
    • Mild SaO2 decrease reduced HF in REM sleep and increased LF in NREM stage 2, amplifying existing abnormalities.

    Conclusions:

    • Infants with severe BPD exhibit altered autonomic control during sleep.
    • Mild hypoxemia significantly exacerbates ANS dysfunction in these infants.
    • Findings highlight the vulnerability of ANS regulation in BPD to oxygen level changes.