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Simple dysphasic seizures as the sole manifestation of relapse in multiple sclerosis

J Spatt1, G Goldenberg, B Mamoli

  • 1Ludwig Boltzmann Institut für Epilepsie, II. Neurolog. ABT., Neurologisches Krankenhaus Rosenhügel, Vienna, Austria.

Epilepsia
|November 1, 1994
PubMed

Insights

In multiple sclerosis (MS) patients, dysphasic seizures can signal a relapse. This case highlights the link between seizures, EEG findings, and MRI-confirmed brain lesions in MS.

Area of Science:

  • Neurology
  • Neuroimmunology
  • Neurophysiology

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Relapses in MS can present with diverse neurological symptoms.
  • Epileptiform discharges and seizures are recognized, though less common, manifestations in MS.

Observation:

  • A patient with known multiple sclerosis presented with dysphasic seizures as the sole symptom of a disease relapse.
  • Continuous EEG monitoring revealed a correlation between seizure activity and specific EEG patterns.
  • A focal EEG abnormality was identified, corresponding to a specific brain region.

Findings:

  • Magnetic resonance imaging (MRI) confirmed an active encephalitic plaque in the left temporal lobe.
  • The temporal lobe lesion was strongly correlated with the localized EEG focus.
  • The time course of the dysphasic seizures closely mirrored the observed EEG changes.

Implications:

  • This case underscores the importance of considering seizures as a potential MS relapse symptom, particularly in the temporal lobe.
  • It emphasizes the utility of correlating EEG findings with neuroimaging (MRI) for accurate diagnosis and localization of MS activity.
  • Understanding these correlations can aid in timely and targeted therapeutic interventions for MS relapses.

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