Related Experiment Video
Updated: Jun 10, 2026

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
Determination of left ventricular volume by two-dimensional echocardiography: comparison with magnetic resonance
M C Herregods1, G De Paep, B Bijnens
1Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
Insights
A new 2D echocardiography method accurately measures left ventricular volume in healthy volunteers. This technique shows minimal variability and is comparable to reference magnetic resonance imaging, even with poor echogenicity.
Area of Science:
- Cardiology
- Medical Imaging
- Echocardiography
Background:
- Accurate assessment of left ventricular (LV) volume is crucial for cardiovascular diagnosis.
- Traditional echocardiographic methods may face limitations in precision and accuracy.
- Magnetic resonance imaging (MRI) is often considered the reference standard for LV volume quantification.
Purpose of the Study:
- To evaluate a novel two-dimensional (2D) echocardiographic delineation method for determining left ventricular volume.
- To compare the accuracy of this new echocardiographic technique against magnetic resonance imaging (MRI).
- To assess the reproducibility and potential advantages of the new echocardiographic method.
Main Methods:
- A newly developed 2D echocardiographic delineation method was used to measure LV volumes in 12 healthy volunteers.
- Measurements included left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV).
- Left ventricular ejection fraction (LVEF) was also calculated and compared with MRI reference values.
Main Results:
- Echocardiographically determined LVEDV was 123 ± 12 ml versus 121 ± 12 ml by MRI.
- Echocardiographically determined LVESV was 41 ± 7 ml versus 37 ± 6 ml by MRI.
- Echocardiographically determined LVEF was 67 ± 4% versus 70 ± 5% by MRI, with no statistical differences observed for any parameter.
Conclusions:
- The novel 2D echocardiographic delineation method accurately quantifies left ventricular volume in healthy individuals.
- The method demonstrated minimal interstudy and inter-observer variability, suggesting high reproducibility.
- Advantages include a dynamic display for precise edge-detection and easy correction, enhancing accuracy even in cases of poor echogenicity.
Abstract:
Left ventricular volume was determined in 12 healthy volunteers using a newly developed two-dimensional echocardiographic delineation method. The results were compared with those of magnetic resonance imaging, which served as the method of reference. Left ventricular end-diastolic volume was 123 +/- 12 ml, echocardiographically defined, and 121 +/- 12 ml calculated with magnetic resonance imaging. End-systolic volume was 41 +/- 7 ml on echocardiography and 37 +/- 6 ml on magnetic resonance imaging. Left ventricular ejection fraction was 67 +/- 4%, echocardiographically defined, and 70 +/- 5%, calculated with magnetic resonance imaging. There was no statistical difference for any of the measured parameters. Interstudy and inter-observer variability was minimal. In conclusion, in healthy volunteers left ventricular volume was accurately defined, using this newly developed two-dimensional echocardiographic delineation method. During endocardial delineation a dynamic display is continuously available on a second window, allowing precise visual edge-detection. Moreover, corrections can be made easily and quickly. These two advantages enhance the accuracy of the method, even in cases of poor echogenicity.
Related Concept Videos
Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...

