Related Experiment Video

Updated: Jun 23, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

Quality of life on enalapril after acute myocardial infarction

O Ekeberg1, T O Klemsdal, S E Kjeldsen

  • 1Department of Internal Medicine, Ullevaal Hospital, Oslo, Norway.

European Heart Journal
|August 1, 1994
PubMed

Insights

Enalapril did not significantly improve quality of life after myocardial infarction compared to placebo. However, factors like angina, heart failure, and smoking negatively impacted patients' quality of life.

Area of Science:

  • Cardiology
  • Clinical Research
  • Quality of Life Studies

Background:

  • Acute myocardial infarction (MI) significantly impacts patient quality of life.
  • Understanding factors influencing post-MI recovery is crucial for patient management.
  • Enalapril is an ACE inhibitor often used in cardiovascular disease management.

Purpose of the Study:

  • To assess the effect of enalapril versus placebo on quality of life 4-6 months post-MI.
  • To identify demographic and clinical factors associated with quality of life after MI.

Main Methods:

  • Randomized, double-blind, placebo-controlled study.
  • Quality of life assessed using Nottingham Health Profile (NHP), Physical Symptoms Distress Index (PSDI), Work Performance Scale (WPS), and Life Satisfaction Index (LSI).
  • Study included 36 women and 96 men, with data analyzed for demographic and clinical subgroups.

Main Results:

  • No significant difference in overall quality of life between enalapril and placebo groups.
  • Men reported better quality of life than women; non-smokers/ex-smokers reported better quality of life than smokers.
  • Patients with angina pectoris or congestive heart failure reported worse quality of life.

Conclusions:

  • Enalapril treatment did not improve quality of life post-MI compared to placebo.
  • Angina, heart failure, and smoking are associated with reduced quality of life in post-MI patients.
  • Further research may explore interventions targeting these specific factors to enhance recovery.

More Related Videos

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Angina V: Nursing Management01:20

Angina V: Nursing Management

Angina, a symptom of myocardial ischemia, requires a structured nursing management approach to ensure effective care and prevent complications like myocardial infarction. Comprehensive nursing care involves assessing, diagnosing, planning, implementing interventions, and evaluating outcomes, all tailored to the individual patient's needs.Patient AssessmentNursing assessment begins with a detailed subjective evaluation of symptoms, which typically include chest pain or pressure radiating to the...
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...