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Interleukin-10 and pentoxifylline inhibit C-reactive protein-induced tissue factor gene expression in peripheral
M Ramani1, F Khechai, V Ollivier
1INSERM U294, CHU Xavier Bichat, Paris, France.
FEBS Letters
|December 12, 1994
Abstract:
Fibrin deposition is an integral feature of the inflammatory response. In response to C-reactive protein (CRP), an acute-phase reactant, blood monocytes synthesize and express tissue factor (TF), the main initiator of blood coagulation. We report the inhibitory effect of interleukin 10 (IL-10) and that of pentoxifylline, a methyl xanthine derivative, on monocyte expression of TF activity, TF protein and TF mRNA in response to CRP. These agents may be of use in diseases where a TF-induced prothrombotic state is detrimental.