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Somatostatin in human follicular fluid
1Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.
Human Reproduction (Oxford, England)
|August 1, 1994
Summary
Somatostatin is present in human follicular fluid and its levels are higher than in plasma. Follicular fluid somatostatin correlates with progesterone, suggesting a role in follicular maturation.
Area of Science:
- Reproductive Endocrinology
- Biochemistry
Background:
- Somatostatin is a peptide hormone with diverse physiological roles.
- Its presence and function in human follicular fluid are not well-established.
Purpose of the Study:
- To determine somatostatin levels in human pre-ovulatory follicular fluid.
- To investigate the potential role of somatostatin in follicular maturation and luteinization.
Main Methods:
- Follicular fluid and plasma samples were collected from 66 women undergoing in-vitro fertilization.
- Concentrations of somatostatin, oestradiol, progesterone, and androstenedione were measured using immunoassay.
Main Results:
- Follicular fluid somatostatin concentrations were significantly higher than plasma concentrations.
- Follicular fluid somatostatin positively correlated with progesterone levels.
- No correlation was found with oestradiol, androstenedione, follicular size, or oocyte fertilization status.
Conclusions:
- Somatostatin is present in human follicular fluid at concentrations higher than in plasma.
- The positive correlation with progesterone suggests a physiological role for somatostatin in follicular maturation and luteinization.