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Tissue adhesive wound repair revisited
J P Noordzij1, P A Foresman, G T Rodeheaver
1Department of Plastic Surgery, University of Virginia School of Medicine, Charlottesville 22908.
The Journal of Emergency Medicine
|September 1, 1994
Summary
Tissue adhesive (N-butyl-2-cyanoacrylate) demonstrated superior resistance to bacterial infection compared to polypropylene sutures. While sutures initially offered greater wound strength, tissue adhesive achieved comparable strength within seven days, with faster application and reduced skill requirements.
Area of Science:
- Wound healing
- Surgical materials science
- Infectious disease
Background:
- Percutaneous polypropylene sutures are a common method for wound closure.
- Tissue adhesives offer an alternative wound closure technique with potential benefits.
Purpose of the Study:
- To compare the efficacy of N-butyl-2-cyanoacrylate tissue adhesive versus percutaneous polypropylene suture in resisting wound infection and assessing wound strength.
- To evaluate the impact of each closure method on host defenses and bacterial growth.
Main Methods:
- Experimental study comparing tissue adhesive and percutaneous suture closure in wounds.
- Assessment of bacterial growth levels and wound breaking strength at immediate and seven-day intervals post-closure.
Main Results:
- Percutaneous sutures significantly increased bacterial growth compared to tissue adhesive.
- Initially, sutures provided superior wound breaking strength, but this difference diminished by seven days.
- Tissue adhesive closure was faster and required less psychomotor skill.
Conclusions:
- N-butyl-2-cyanoacrylate tissue adhesive is more effective at preventing wound infection than polypropylene sutures.
- Tissue adhesives offer comparable wound strength to sutures after seven days and are a more practical closure method.