Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prognosis in therapy-resistant hypertension

H Isaksson1, J Ostergren

  • 1Department of Cardiology, Söder Hospital Stockholm, Sweden.

Journal of Internal Medicine
|December 1, 1994
PubMed
Summary

Therapy-resistant hypertension (RH) persists despite aggressive treatment and is linked to a higher risk of stroke, renal insufficiency, and diabetes. This highlights the need for continued research into underlying mechanisms and improved management strategies for RH patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal murine skeletogenesis partially recovers from absent skeletal muscle as development progresses.

European cells & materials·2022
Same author

Phase-contrast enhanced synchrotron micro-tomography of human meniscus tissue.

Osteoarthritis and cartilage·2022
Same author

A practical guide for in situ mechanical testing of musculoskeletal tissues using synchrotron tomography.

Journal of the mechanical behavior of biomedical materials·2022
Same author

Tendon mechanobiology in small-animal experiments during post-transection healing.

European cells & materials·2021
Same author

Correction to: Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

Prednisolone treatment reduces the osteogenic effects of loading in mice.

Bone·2018

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Therapy-resistant hypertension (RH) poses a significant clinical challenge, often requiring intensive management.
  • Understanding the long-term prognosis of RH is crucial for patient care and risk stratification.

Purpose of the Study:

  • To investigate the prognosis of patients with therapy-resistant hypertension (RH).
  • To compare the outcomes of RH patients with age- and sex-matched hypertensives responding to treatment.

Main Methods:

  • A 7-year follow-up study involving outpatients at a secondary referral center for hypertension.
  • Inclusion criteria for RH: age <= 65, no secondary hypertension, triple-drug therapy, diastolic blood pressure > target, no history of major cardiovascular events or renal failure, and documented compliance.

Related Experiment Videos

  • Thirty-six RH patients were compared with 72 age- and sex-matched controls, with continuous efforts to optimize blood pressure control in all participants.

    • Main Results:

    • RH patients had slightly higher blood pressure (2/6 mmHg) than controls at follow-up.
    • RH was associated with a significantly increased incidence of stroke (P < 0.05), renal insufficiency (P < 0.05), and non-insulin-dependent diabetes mellitus (NIDDM) (P < 0.05).
    • RH patients faced a 2.71-fold increased risk of adverse events during the 7-year follow-up (P < 0.05).

    Conclusions:

    • Therapy-resistant hypertension (RH) is associated with a poorer prognosis, including an elevated risk of stroke and target organ damage, particularly renal insufficiency.
    • Persistence of RH despite aggressive, compliant treatment suggests underlying mechanisms that warrant further investigation.
    • The observed association between RH, obesity, and NIDDM suggests a potential role for hyperinsulinemia in the development of therapy resistance.