Polymorphisms in the gene encoding angiotensin 1-converting enzyme and relationship to its post-translational product...

There is increasing evidence to suggest that the gene encoding angiotensin 1-converting enzyme (ACE) plays a significant part in cardiac disease risk. It is not clear if this risk is due to atherosclerotic factors in general or whether its influence is local to cardiac tissue. Previous studies have suggested that there is a genetic control of plasma ACE levels in normal subjects. We sought to see if such a relationship also existed amongst computer tomography (CT) proven cerebral infarction. Twenty-eight patients with stroke and 19 control subjects were grouped according to their ACE genotype and their plasma ACE levels were assessed. Although there is a trend for plasma levels to be associated with the variant ACE alleles there was a wide overlap. However, when compared with their respective alleles in control subjects there was no difference. We conclude that any future evaluation of stroke risk from the ACE gene will need to determine both plasma ACE level and genotype.