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4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere: synthesis and biological evaluation
A Datta1, L R Jayasinghe, G I Georg
1Department of Medicinal Chemistry, University of Kansas, Lawrence 66045.
Journal of Medicinal Chemistry
|November 25, 1994
Abstract:
4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.