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[Antimicrobial activities of ciprofloxacin against recently obtained clinical isolates]
Abstract:
In order to evaluate antimicrobial activity of ciprofloxacin (CPFX), minimum inhibitory concentrations (MICs) of CPFX and other drugs were determined against clinical isolates that were obtained in our laboratory from January to December of 1991, and of 1993. The results are summarized as follows: 1. CPFX-resistant strains were on the increase in various strains, compared to those in the early 1980s. However, many of CPFX-resistant strains were multi-drug resistant including beta-lactams. In addition, they showed cross resistance to other fluoroquinolone agents. 2. MIC distribution of other drugs suggested that there were increased frequencies of benzylpenicillin (PCG)-insensitive Streptococcus pneumoniae (PISP) and CEPs-resistant Escherichia coli. However, MIC distribution of CPFX to these resistant strains were in a relatively low range. 3. When isolates of 1991 were compared to those of 1993, we confirmed that CPFX-resistant strains decreased among certain bacteria such as Staphylococcus aureus. Also we confirmed that fewer CPFX-resistant strains were found among bacteria that may be highly related to infections encountered in daily medical care.
Insights
Ciprofloxacin resistance increased overall but decreased in some bacteria like Staphylococcus aureus between 1991 and 1993. Many resistant strains showed multi-drug resistance to other antibiotics.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Context:
- Antimicrobial resistance is a growing global health concern.
- Monitoring resistance patterns is crucial for effective treatment strategies.
- Ciprofloxacin (CPFX) is a widely used fluoroquinolone antibiotic.
Purpose:
- To evaluate the antimicrobial activity of ciprofloxacin (CPFX) against clinical isolates.
- To determine the minimum inhibitory concentrations (MICs) of CPFX and other drugs.
- To track changes in antimicrobial resistance patterns over time.
Summary:
- CPFX-resistant strains increased compared to the early 1980s, often exhibiting multi-drug resistance and cross-resistance to other fluoroquinolones.
- Increased frequencies of penicillin-insensitive Streptococcus pneumoniae (PISP) and cephalosporin-resistant Escherichia coli were observed.
- However, MICs of CPFX against these resistant strains remained relatively low.
- Between 1991 and 1993, a decrease in CPFX-resistant strains was noted in Staphylococcus aureus and bacteria associated with common medical care infections.
Impact:
- Findings highlight the dynamic nature of antimicrobial resistance.
- Informs clinical decision-making regarding antibiotic use and stewardship.
- Provides data for public health surveillance of antibiotic resistance trends.