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[A clinicobacteriologic study on sultamicillin fine granules in pediatric sinusitis]
R Sugita1, K Deguchi, Y Fujimaki
1Sugita Otorhinolaryngologic Clinic.
The Japanese Journal of Antibiotics
|September 1, 1994
Summary
Sultamicillin showed 77.5% clinical efficacy in pediatric sinusitis, despite challenges with penicillin-insensitive Streptococcus pneumoniae. Further research is needed to address antibiotic resistance in pediatric respiratory infections.
Area of Science:
- Pediatric infectious diseases
- Clinical microbiology
- Pharmacology
Background:
- Pediatric sinusitis is a common condition often treated with antibiotics.
- The rise of antibiotic-resistant bacteria, particularly penicillin-insensitive Streptococcus pneumoniae (PISP), poses a therapeutic challenge.
- Understanding the microbiological landscape and treatment efficacy is crucial for managing pediatric sinusitis.
Purpose of the Study:
- To evaluate the clinical efficacy and bacteriological impact of sultamicillin in treating pediatric sinusitis.
- To identify the primary bacterial pathogens involved in pediatric sinusitis.
- To assess the prevalence and persistence of PISP in pediatric sinusitis cases.
Main Methods:
- A multicenter study involving 10 general practice settings.
- Clinical and bacteriological assessments of pediatric patients with sinusitis.
- Isolation and identification of bacterial pathogens from nasal discharge and nasopharynx.
- Determination of minimum inhibitory concentrations (MICs) for Streptococcus pneumoniae.
Main Results:
- Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were the major isolates.
- 33% of isolated S. pneumoniae were penicillin-insensitive (PISP), with MICs ≥ 0.1 µg/ml.
- PISP was found in 14% of all cases, with higher persistence rates (38.5-60.0%) compared to susceptible strains and other bacteria.
- Sultamicillin demonstrated a satisfactory clinical efficacy rate of 77.5%.
- Adverse reactions, primarily diarrhea and loose stools, occurred in 21.5% of patients.
Conclusions:
- Sultamicillin is clinically effective in pediatric sinusitis, but its efficacy may be impacted by the prevalence of PISP.
- The high persistence rate of PISP highlights the need for strategies to combat antibiotic resistance in pediatric respiratory infections.
- Monitoring bacterial resistance patterns is essential for optimizing antibiotic therapy in pediatric sinusitis.