Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hirschsprung's disease in newborns]

E A Stepanov, T V Krasovskaia, I D Muratov

    Khirurgiia
    |August 1, 1994
    PubMed
    Summary

    This study on Hirschsprung's disease in infants found rectosigmoid involvement most common. Many infants presented with abdominal distention and meconium retention, often linked to enterocolitis and bacterial imbalance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sub-cycle pulse revealed with carrier-envelope phase control of soliton self-compression in anti-resonant hollow-core fiber.

    Optics letters·2023
    Same author

    Direct Observation of Incommensurate-Commensurate Transition in Graphene-hBN Heterostructures via Optical Second Harmonic Generation.

    ACS applied materials & interfaces·2020
    Same author

    Chirp-controlled high-harmonic and attosecond-pulse generation via coherent-wake plasma emission driven by mid-infrared laser pulses.

    Optics letters·2020
    Same author

    High-order harmonic analysis of anisotropic petahertz photocurrents in solids.

    Optics letters·2019
    Same author

    Heisenberg-exchange-free nanoskyrmion mosaic.

    Journal of physics. Condensed matter : an Institute of Physics journal·2019
    Same author

    Effective Heisenberg Model and Exchange Interaction for Strongly Correlated Systems.

    Physical review letters·2018

    Area of Science:

    • Pediatric Surgery
    • Gastroenterology
    • Neonatology

    Background:

    • Hirschsprung's disease is a congenital disorder affecting the large intestine.
    • It causes obstruction due to the absence of nerve cells in the bowel wall.
    • Early diagnosis and treatment are crucial for infant outcomes.

    Purpose of the Study:

    • To analyze the clinical presentation, diagnostic methods, and treatment outcomes in infants with Hirschsprung's disease.
    • To determine the prevalence of different forms of Hirschsprung's disease.
    • To evaluate the association between bacterial flora, enterocolitis, and disease severity.

    Main Methods:

    • Retrospective analysis of 52 newborn and infant cases.
    • Clinical examination, including assessment of meconium passage, vomiting, and abdominal distention.
    • Diagnostic imaging (irrigography with rectosigmoid ratio calculation).
    • Histochemical and histological examinations for aganglionosis.
    • Assessment of intestinal bacterial flora and enterocolitis.

    Main Results:

    • The rectosigmoid form (36.5%) was the most common, followed by subtotal (23.1%) and total (25%).
    • Key clinical signs included abdominal distention (100%), meconium retention (94.2%), and vomiting (75%).
    • 68.5% of patients exhibited bacterial dysbiosis and enterocolitis, correlating with disease severity.

    Conclusions:

    • Hirschsprung's disease presents with distinct clinical features in infants.
    • A combination of imaging and histological methods is essential for diagnosis.
    • Bacterial imbalance and enterocolitis are significant complications requiring management alongside surgical intervention.

    Related Experiment Videos