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Pregnancy and movement disorders

L I Golbe1

  • 1Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick.

Neurologic Clinics
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

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Pregnancy and movement disorders are rare, with limited data on medication safety. Some medications should be stopped before pregnancy, and most movement disorders have minimal impact on pregnancy outcomes.

Area of Science:

  • Neurology
  • Obstetrics

Background:

  • Pregnancy and movement disorders co-occur infrequently.
  • Limited clinical experience exists for managing pregnancy in movement disorder patients, except possibly Wilson's disease (WD).
  • Patient concerns focus on medication safety and long-term childcare ability.

Purpose of the Study:

  • To review the management of pregnancy in patients with movement disorders.
  • To address concerns regarding medication efficacy and toxicity during pregnancy.
  • To evaluate the impact of movement disorders on pregnancy and childbirth.

Main Methods:

  • Literature review and clinical experience synthesis.
  • Analysis of medication efficacy and toxicity profiles.
  • Assessment of movement disorder effects on pregnancy and neonatal outcomes.

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Main Results:

  • Certain medications (neuroleptics, amantadine, diazepam, primidone, selegiline, reserpine) may require discontinuation before pregnancy.
  • Pregnancy can unmask chorea gravidarum and mildly worsen Parkinson's disease (PD) symptoms.
  • Most movement disorders have minimal impact on pregnancy, childbirth, and neonatal health.

Conclusions:

  • Careful medication management is crucial for pregnant patients with movement disorders.
  • Movement disorders generally pose minimal risk to pregnancy, childbirth, and neonates.
  • Further research is needed to address data gaps in medication safety during pregnancy.