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Updated: Sep 2, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
[Measles in The Netherlands; epidemiology and the effect of vaccination]
C W van der Zwan1, A D Plantinga, H C Rümke
1Rijksinstituut voor Volksgezondheid en Milieuhygiëne, Bilthoven.
Objective:
To estimate the incidence of measles in the Netherlands and assess the effect of vaccination with regard to vaccination status.
Design:
Retrospective study.
Method:
Data were collected from the Central Bureau for Statistics (CBS), reported cases at the National Health Department (NHD), data from hospitals concerning admissions, morbidity data from the General Practitioner Networks, serological data from virology laboratories and serological data from several other studies.
Results:
After introduction of the measles vaccination in 1976, morbidity and reported cases decreased dramatically. Some data suggest that measles in children over 10 years old are reported more frequently. Death caused by measles did not occur after 1988.
Conclusion:
The massive vaccination since 1976 resulted in an initial decrease in incidence of measles. The increase in incidence thereafter was probably caused by an increase in, and crowding of vulnerable, older people. No effect on the severity of the complications were seen so far. Surveillance is necessary to follow groups at risk and to take proper preventive measures.
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