Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cross-matched platelets in bone marrow transplantation

S A Rule1, W N Erber, J A Lown

  • 1Department of Haematology, Royal Perth Hospital, Western Australia.

Pathology
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systemic adjuvant and perioperative chemotherapy following curative-intent liver metastasectomy in colorectal cancer-is it justified?

ESMO gastrointestinal oncology·2026
Same author

Ethnic inequality in place of death: Analysis using 'gold standard' self-reported ethnicity data from the Census Longitudinal Study.

Palliative medicine·2025
Same author

Social determinants of where people die: A study of moderators and mediators using linked UK Census and mortality data.

SSM - population health·2025
Same author

Effects of climate and environmental factors on childhood and adolescent asthma: A systematic review based on spatial and temporal analysis evidence.

The Science of the total environment·2024
Same author

Metabarcoding airborne pollen from subtropical and temperate eastern Australia over multiple years reveals pollen aerobiome diversity and complexity.

The Science of the total environment·2022
Same author

Spatial origin of the extracellular ATP-induced cytosolic calcium signature in Arabidopsis thaliana roots: wave formation and variation with phosphate nutrition.

Plant biology (Stuttgart, Germany)·2022

Routine screening for Human Leukocyte Antigen (HLA) antibodies and cross-matching platelets significantly improves support for multiply-transfused patients, preventing refractoriness without needing HLA-typed donors.

Area of Science:

  • Immunology
  • Hematology
  • Transplantation

Background:

  • Antibodies to Human Leukocyte Antigens (HLA) pose a significant challenge in multiply-transfused patients, particularly bone marrow transplant recipients.
  • Managing thrombocytopenia in these patients requires effective strategies to prevent platelet refractoriness.

Purpose of the Study:

  • To evaluate the efficacy of routine HLA antibody screening and cross-matched random donor platelet (XMRDP) transfusions in bone marrow transplant recipients.
  • To determine if this approach can prevent clinical platelet refractoriness and ensure adequate platelet support.

Main Methods:

  • A prospective study screened 44 bone marrow transplant recipients weekly for HLA antibodies using a solid phase red cell adherence technique.
  • An adapted method provided XMRDP for antibody-positive patients, transitioning from random donor platelets (RDP).

Related Experiment Videos

Main Results:

  • Twelve of 44 patients (27%) developed HLA antibodies, with 6 before and 6 after transplantation.
  • Four patients who developed antibodies post-transplant showed improved platelet increments after switching to XMRDP.
  • No significant bleeding events were observed during the study.

Conclusions:

  • Routine HLA antibody screening and platelet cross-matching provide effective support for thrombocytopenic patients.
  • This strategy avoids the need for HLA-typed blood donors and successfully prevents clinical platelet refractoriness.