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Structure, localization, and action of buccalin B: a bioactive peptide from Aplysia
F S Vilim1, E C Cropper, S C Rosen
1Center for Neurobiology and Behavior, New York State Psychiatric Institute, Columbia University, NY 10032.
Peptides
|January 1, 1994
Abstract:
The cholinergic motor neurons for the accessory radula closer (ARC) contain several neuropeptides that affect muscle contractions. In the present study, we have purified and sequenced a sixth ARC neuropeptide, using a combination of high pressure liquid chromatography and bioassays. This neuropeptide, Gly-Leu-Asp-Arg-Tyr-Gly-Phe-Val-Gly-Gly-Leu-amide, has been named buccalin B (BUCb) because it is significantly homologous to the previously characterized neuropeptide buccalin A. BUCb was found to be two-three times more potent than buccalin A in depressing motor neuron induced contractions.