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Haemoglobin A1, blood glucose, and high-density lipoprotein cholesterol in insulin-requiring diabetics

R S Elkeles, J Wu, J Hambley

    Lancet (London, England)
    |September 9, 1978
    PubMed

    Insights

    Glycated hemoglobin A1 (HbA1) levels correlate with blood glucose in diabetics. However, HbA1 does not reliably predict high-density lipoprotein (HDL) cholesterol levels in these patients.

    Area of Science:

    • Endocrinology
    • Metabolic Diseases
    • Clinical Chemistry

    Background:

    • Diabetes mellitus management requires monitoring glycemic control.
    • Glycated hemoglobin A1 (HbA1) reflects long-term blood glucose levels.
    • High-density lipoprotein (HDL) cholesterol is a key cardiovascular risk factor.

    Purpose of the Study:

    • To investigate the correlation between HbA1 and blood glucose levels.
    • To examine the relationship between HbA1, blood glucose, and HDL cholesterol in insulin-requiring diabetics.
    • To assess HbA1 as a predictor of HDL cholesterol concentration.

    Main Methods:

    • Study included forty insulin-requiring diabetic patients.
    • Measured HbA1 and concurrent blood glucose.
    • Assessed mean clinic blood glucose over the previous year.
    • Measured high-density lipoprotein (HDL) cholesterol concentration.

    Main Results:

    • A significant correlation was found between HbA1 and concurrent blood glucose.
    • Significant correlation observed between HbA1 and mean clinic blood glucose over the prior year.
    • No significant correlation was detected between HbA1 and HDL cholesterol concentration.
    • No significant correlation was found between blood glucose and HDL cholesterol concentration.

    Conclusions:

    • HbA1 is a reliable indicator of recent glycemic control in insulin-requiring diabetics.
    • HbA1 is not a suitable predictor for HDL cholesterol levels in this patient group.
    • Assessing HDL cholesterol requires direct measurement, independent of glycemic control markers like HbA1.

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