Related Experiment Videos
Filipin test for diagnosis of Niemann-Pick disease type C
1Laboratory of Protein Metabolism, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Sbornik Lekarsky
|January 1, 1993
Abstract:
The test is based on the reaction of unesterified cholesterol with fluorescent antibiotic filipin giving a strongly fluorescent, stable cholesterol-filipin complex suitable for in situ detection. The test is useful for the evaluation of impaired cholesterol esterification in cultured cells (fibroblasts or others) in Niemann-Pick disease type C.