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[Pregnancy after chemotherapy in malignant forms of gestational trophoblastic disease]
1Centrum pro trofoblastickou nemoc, lékarské fakulty Univerzity Karlovy, Praha.
The authors reviewed the subsequent pregnancy experience in patients with malignant gestational trophoblastic disease who were managed at the Czechoslovak Trophoblastic Disease Center between January 1981 to December 1990. Thirty-five women who conceived following successful chemotherapy of gestational trophoblastic disease subsequently became pregnant a total of 53 times. Twenty-seven of these 53 pregnancies or 51% terminated in live-born infants. Major or minor congenital malformations were not detected. Those subsequent pregnancies concluded in 23 full-term deliveries (85%) and 4 premature births (15%). Primary cesarean section was performed for 5 (19%) women. Three or 6% ended in spontaneous abortion, one or 2% ended in mola hydatidosa partialis and mola hydatidosa completa. Sixteen pregnancies or 30% terminated in therapeutic abortion. Five women or 9% are now pregnant. Those patients who are treated successfully with chemotherapy should be reassured that they can anticipate a normal reproductive outcome in later conceptions.
The authors reviewed the subsequent pregnancy experience in patients with malignant gestational trophoblastic disease who were managed at the Czechoslovak Trophoblastic Disease Center between January 1981 to December 1990. Thirty-five women who conceived following successful chemotherapy of gestational trophoblastic disease subsequently became pregnant a total of 53 times. Twenty-seven of these 53 pregnancies or 51% terminated in live-born infants. Major or minor congenital malformations were not detected. Those subsequent pregnancies concluded in 23 full-term deliveries (85%) and 4 premature births (15%). Primary cesarean section was performed for 5 (19%) women. Three or 6% ended in spontaneous abortion, one or 2% ended in mola hydatidosa partialis and mola hydatidosa completa. Sixteen pregnancies or 30% terminated in therapeutic abortion. Five women or 9% are now pregnant. Those patients who are treated successfully with chemotherapy should be reassured that they can anticipate a normal reproductive outcome in later conceptions.