[Determination of salbutamol in human urine]

Salbutamol (2.4 mg) was administrated to a healthy male. The urine was analysed by GC-MS. 95% of the drug was excreted in 24 h in unconjugated form. The pH of urine was shown to strongly affect the extraction rate, good recovery was obtained at pH 8.8. With this method, salbutamol can be determined simply, quickly and accurately.