Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical problems with HLA sensitization

H F Polesky

    Progress in Clinical and Biological Research
    |January 1, 1976
    PubMed
    Summary

    Frozen-thawed-deglycerolized red cells (FTDRC) offer the lowest HLA antigen levels, making them suitable for specific patient groups. Further research is needed to understand HLA sensitization and potential benefits in renal allograft survival.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Inbreeding, heterozygosity, and lymphoma risk among the baboons (Papio hamadryas) of Sukhumi, USSR.

    American journal of primatology·2020
    Same author

    The use and abuse of the full-sibling and half-sibling indices.

    Transfusion·2000
    Same author

    Impact of molecular (DNA) testing on determination of parentage.

    Archives of pathology & laboratory medicine·1999
    Same author

    Improving the safety of transfusion therapy.

    Clinics in laboratory medicine·1996
    Same author

    How much fresh, low-titer, O-negative blood is available?

    Transfusion·1996
    Same author

    Long-term follow-up of blood donors with indeterminate human immunodeficiency virus type 1 results on Western blot.

    Transfusion·1995

    Area of Science:

    • Transfusion Medicine
    • Immunology
    • Hematology

    Background:

    • Frozen-thawed-deglycerolized red cells (FTDRC) are a red blood cell component with minimal Human Leukocyte Antigen (HLA) expression.
    • Patients with repetitive nonhemolytic febrile reactions, those awaiting renal allografts, and immunodeficient individuals at risk for Graft-versus-Host Disease (GVHD) are potential recipients.

    Purpose of the Study:

    • To highlight the low HLA antigen content of FTDRC.
    • To define the indications for using FTDRC in specific patient populations.
    • To address unresolved questions regarding HLA sensitization and the impact of FTDRC transfusion on renal allograft survival.

    Main Methods:

    • Review of existing literature and clinical practices regarding FTDRC preparation and use.
    • Discussion of immunological principles related to HLA antigen exposure and sensitization.
    • Identification of key areas requiring further investigation.

    Main Results:

    • FTDRC possess the least amount of HLA antigen among all red cell components.
    • FTDRC are indicated for patients experiencing nonhemolytic febrile reactions and are likely beneficial for patients awaiting renal allografts and immunodeficient patients at risk of GVHD.

    Conclusions:

    • FTDRC are a valuable option for transfusion in specific patient populations due to their low HLA antigen content.
    • Further research is essential to determine the minimum sensitizing dose of HLA, the role of cellular debris, and the potential immunomodulatory effects of FTDRC on renal allograft survival.

    Related Experiment Videos