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Related Experiment Videos

Cisapride

P M Hubbard

    ANNA Journal
    |October 1, 1994
    PubMed
    Summary
    This summary is machine-generated.

    Cisapride, a prokinetic agent, effectively improves upper gastrointestinal motility and emptying in renal patients undergoing long-term dialysis. While generally well-tolerated, common adverse effects include gastrointestinal issues like cramps and diarrhea.

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    Area of Science:

    • Nephrology
    • Gastroenterology
    • Pharmacology

    Background:

    • Renal patients frequently experience vague abdominal symptoms suggestive of gastric motility disorders.
    • Gastric stasis is a common complication in patients with chronic kidney disease and those on long-term dialysis.

    Purpose of the Study:

    • To evaluate the efficacy of cisapride in improving upper gastrointestinal motility and emptying in patients on long-term dialysis.
    • To assess the safety and tolerability profile of cisapride in this patient population.

    Main Methods:

    • Administration of cisapride to patients on long-term dialysis experiencing upper gastrointestinal symptoms.
    • Assessment of gastric motility and emptying parameters before and after cisapride treatment.
    • Monitoring for adverse reactions and side effects.

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    Main Results:

    • Cisapride significantly improved motility and emptying of the upper gastrointestinal tract.
    • The drug is extensively metabolized in the liver, yielding metabolites with minimal pharmacologic activity.
    • The primary adverse reactions observed were gastrointestinal, including abdominal cramps, flatulence, and diarrhea.

    Conclusions:

    • Cisapride is an effective prokinetic agent for managing upper gastrointestinal motility disorders in patients on long-term dialysis.
    • The observed adverse effects are predominantly gastrointestinal and generally manageable.
    • Further research may explore optimal dosing and long-term safety in this specific cohort.