Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Individual genes underlying quantitative traits: molecular and analytical methods

E Routman1, J M Cheverud

  • 1Department of Anatomy & Neurobiology, Washington University School of Medicine, St. Louis, MO 63110.

EXS
|January 1, 1994
PubMed
Summary

Innovations in genetics enable the study of quantitative trait loci (QTL). New molecular and analytical techniques allow for the identification, localization, and quantification of QTL effects, advancing evolutionary biology research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic correlations between cartilage regeneration and degeneration reveal an inverse relationship.

Osteoarthritis and cartilage·2020
Same author

RNA-seq analysis of chondrocyte transcriptome reveals genetic heterogeneity in LG/J and SM/J murine strains.

Osteoarthritis and cartilage·2020
Same author

Rate of evolutionary change in cranial morphology of the marsupial genus Monodelphis is constrained by the availability of additive genetic variation.

Journal of evolutionary biology·2015
Same author

Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.

Heredity·2014
Same author

Relationship of age and body mass index to the expression of obesity and osteoarthritis-related genes in human meniscus.

International journal of obesity (2005)·2013
Same author

Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice.

Osteoarthritis and cartilage·2012

Area of Science:

  • Genetics and Evolutionary Biology
  • Molecular Biology

Background:

  • Advances in quantitative and molecular genetics are enabling the study of individual genetic loci influencing complex traits.
  • Quantitative traits are influenced by multiple genes, making their study challenging but crucial.

Purpose of the Study:

  • To review recently developed molecular and analytical techniques for identifying and localizing quantitative trait loci (QTL).
  • To discuss the quantification of QTL effects and their implications.
  • To highlight the growing importance of QTL analysis in evolutionary biology.

Main Methods:

  • Review of recent molecular techniques for genetic analysis.
  • Overview of analytical approaches for QTL identification and localization.
  • Presentation of a case study demonstrating QTL quantification.

Related Experiment Videos

Main Results:

  • Identification and localization of specific quantitative trait loci (QTL) are increasingly feasible.
  • Methods allow for the precise quantification of the effects of individual QTL.
  • The application of these techniques is expanding beyond agriculture and medicine.

Conclusions:

  • Quantitative trait loci (QTL) analysis is a powerful tool for understanding the genetic basis of complex traits.
  • Continued improvements in molecular and analytical techniques will enhance the utility of QTL studies in evolutionary biology.
  • QTL research is becoming indispensable for fields ranging from agriculture to medicine and evolutionary studies.