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Related Experiment Videos

Increased vascular resistance with hemoglobin-based oxygen carriers

J R Hess1, V W Macdonald, C S Gomez

  • 1Division of Blood Research, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129-6800.

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
|January 1, 1994
PubMed
Summary

Hemoglobin-based oxygen carriers increased vascular resistance in swine, limiting their oxygen transport benefits. This effect may negatively impact cardiac function and complicate treatment during hemorrhagic shock resuscitation.

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Area of Science:

  • Biomedical Engineering
  • Critical Care Medicine
  • Resuscitation Science

Background:

  • Hemorrhagic shock necessitates prompt fluid resuscitation to restore oxygen delivery.
  • Hemoglobin-based oxygen carriers (HBOCs) are investigated as alternatives to conventional fluids.
  • Understanding HBOCs' effects on hemodynamics is crucial for clinical application.

Purpose of the Study:

  • To compare HBOCs with conventional resuscitation fluids in a swine model of hemorrhagic shock.
  • To evaluate effects on hemodynamics, oxygen transport, and oxygen consumption.
  • To assess the efficacy of HBOCs in improving physiological parameters.

Main Methods:

  • Immature swine underwent surgical preparation and induced hemorrhagic shock.
  • Animals were resuscitated with Ringer's lactate, albumin, unmodified HBOCs, or crosslinked HBOCs.

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  • Hemodynamic and oxygen transport measurements were recorded for three hours post-resuscitation.

    • Main Results:

    • Hemoglobin-based oxygen carriers significantly increased systemic and pulmonary vascular resistance compared to controls.
    • Oxygen consumption and lactic acidosis correction rates were not improved by HBOC administration.
    • Elevated vascular resistance in HBOC-treated animals limited potential oxygen transport benefits.

    Conclusions:

    • Increased vascular resistance is a significant limitation for cell-free HBOCs in treating hemorrhagic shock.
    • HBOC-induced vasoconstriction may adversely affect cardiac performance and reduce tolerance to blood viscosity changes.
    • Further research is needed to mitigate adverse vascular effects of HBOCs.